Laursen MB, Pakula MM, Gao S, Fluiter K, Mook OR, Baas F, Langklaer N, Wengel SL, Wengel J, Kjems J, Bramsen JB. Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo. Mol Biosyst. 2010 May 10;6(5):862-70. Epub 2010 Feb 9.
Silencing RNAs: organisers and coordinators of complexity in eukaryotic organisms
Posts Tagged ‘Kjems J’
Self-assembly of a nanoscale DNA box with a controllable lid
Andersen ES, Dong M, Nielsen MM, Jahn K, Subramani R, Mamdouh W, Golas MM, Sander B, Stark H, Oliveira CL, Pedersen JS, Birkedal V, Besenbacher F, Gothelf KV, Kjems J. Self-assembly of a nanoscale DNA box with a controllable lid. Nature. 2009 May 7;459(7243):73-6.
A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity.
Bramsen JB, Laursen MB, Nielsen AF, Hansen TB, Bus C, Langkjær N, Babu BR, Højland T, Abramov M, Van Aerschot A, Odadzic D, Smicius R, Haas J, Andree C, Barman J, Wenska M, Srivastava P, Zhou C, Honcharenko D, Hess S, Müller E, Bobkov GV, Mikhailov SN, Fava E, Meyer TF, Chattopadhyaya J, Zerial M, Engels JW, Herdewijn P, Wengel J, Kjems J. A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity.Nucleic Acids Res. 2009 Mar 12. [Epub ahead of print]
miR‐145 induces caspase‐dependent and‐ independent cell death and targets a 22‐gene signature that is upregulated in bladder cancer
Ostenfeld, M.S., Bramsen, J.B., Lamy, P., Villadsen, S.B., Ulhøi, B, Kjems, J., Dyrskjøt, L, Ørntoft, T. miR‐145 induces caspase‐dependent and‐ independent cell death and targets a 22‐gene signature that is upregulated in bladder cancer. Submitted to Cancer Cell 2008
Investigation of particle-functionalized tissue engineering scaffolds using X-ray tomographic microscopy.
Nygaard JV, Andersen MØ, Howard KA, Foss M, Bünger C, Kjems J, Besenbacher F. Investigation of particle-functionalized tissue engineering scaffolds using X-ray tomographic microscopy.
Biotechnol Bioeng. 2008 Jul 1;100(4):820-9.
A 5′ splice site enhances the recruitment of basal transcription initiation factors in vivo.
Damgaard CK, Kahns S, Lykke-Andersen S, Nielsen AL, Jensen TH, Kjems J. A 5′ splice site enhances the recruitment of basal transcription initiation factors in vivo. Mol Cell. 2008 Feb 1;29(2):271-8.
Intracellular siRNA and precursor miRNA trafficking using bioresponsive copolypeptides
Rahbek UL, Howard KA, Oupicky D, Manickam DS, Dong M, Nielsen AF, Hansen TB, Besenbacher F, Kjems J.Intracellular siRNA and precursor miRNA trafficking using bioresponsive copolypeptides. J Gene Med. 2008 Jan;10(1):81-93.
Comparative genomics beyond sequence-based alignments: RNA structures in the ENCODE regions.
Torarinsson E, Yao Z, Wiklund ED, Bramsen JB, Hansen C, Kjems J, Tommerup N, Ruzzo WL, Gorodkin J. Comparative genomics beyond sequence-based alignments: RNA structures in the ENCODE regions. Genome Res. 2007 Dec 20; [Epub ahead of print]
Polycation-based nanoparticle delivery for improved RNA interference therapeutics.
Howard KA, Kjems J. Polycation-based nanoparticle delivery for improved RNA interference therapeutics.
Expert Opin Biol Ther. 2007 Dec;7(12):1811-22. Review.
Semiautomated improvement of RNA alignments
Andersen ES, Lind-Thomsen A, Knudsen B, Kristensen SE, Havgaard JH, Torarinsson E, Larsen N, Zwieb C, Sestoft P, Kjems J, Gorodkin J. Semiautomated improvement of RNA alignments. RNA. 2007 Nov;13(11):1850-9. Epub 2007 Sep 5.