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Welcome to the SIROCCO Project

RNA silencing is a natural mechanism of gene regulation in cells. Small double-stranded RNA molecules 20-28 nucleotides long trigger the degradation of target RNA or DNA, thereby reducing specific gene expression. There is the potential to create small regulatory RNAs (siRNAs) that can be introduced into cells and silence genes that cause diseases.

The goals of the SIROCCO project are

1. to exploit RNA silencing mechanisms in order to improve human and plant health
2. to reveal how siRNAs play a role in developmental biology and disease defense
3. to provide fundamental insights into the genetic networks that underlie normal and diseased embryonic development and adult growth

A detailed description of our research program can be found on our About Page.

Partners have access to a Private Partners page including discounts and reporting documents.

There is also a Data and Bioinformatics site available which aggregates the various bioinformatic and resources developed and hosted by the SIROCCO consortium.

Recent Publications

Csorba T, Burgyán J. Gel mobility shift assays for RNA binding viral RNAi suppressors. Methods Mol Biol. 2011;721:245-52.

Miñones-Moyano E, Porta S, Escaramís G, Rabionet R, Iraola S, Kagerbauer B, Espinosa-Parrilla Y, Ferrer I, Estivill X, Martí E. MicroRNA profiling of Parkinson’s disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function. Hum Mol Genet. 2011 May 10. [Epub ahead of print]

Hansen TB, Kjems J, Bramsen JB. Enhancing miRNA annotation confidence in miRBase by continuous cross dataset analysis. RNA Biol. 2011 May 1;8(3). [Epub ahead of print]

Burgyán J, Havelda Z. Viral suppressors of RNA silencing. Trends Plant Sci. 2011 Mar 23. [Epub ahead of print]

Sonmez C, Bäurle I, Magusin A, Dreos R, Laubinger S, Weigel D, Dean C. RNA 3′ processing functions of Arabidopsis FCA and FPA limit intergenic transcription. Proc Natl Acad Sci U S A. 2011 May 2. [Epub ahead of print]

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